Single-shot, low-dose intratympanic gentamicin in Ménière disease: role of vestibular-evoked myogenic potentials and caloric test in the prediction of outcome

fuente de la imagen: http://www.zipaud.com/Audapedia/VEMP-Resources.aspx
Authors
Sercan Gode MDa, Nese Celebisoy MDb, Aycan Akyuz MDa, Feray Gulec MDb, Hale Karapolat MDc, Cem Bilgen PhDa and Tayfun Kirazli MDa

a Department of Otolaryngology, Ege University Medical School, Izmir, Turkey

b Department of Neurology, Ege University Medical School, Izmir, Turkey

c Department of Physical Medicine and Rehabilitation, Ege University Medical School, Izmir, Turkey



Abstract
Objective

The aim of this study was to assess the efficacy and safety of single and low-dose intratympanic gentamicin therapy in patients with Ménière disease and who were monitored both with caloric tests and vestibular-evoked myogenic potentials (VEMPs) to see if VEMPs have an additional role in predicting the efficacy of the drug.
Study design

This is a prospective cohort study.
Setting

Tertiary referral center is the study setting.
Patients

Twenty-five intractable Ménière disease patients were included as the study group.
Intervention(s)

Low-dose (16 mg/mL), single-shot intratympanic gentamicin was applied. VEMP and caloric test were applied 2 weeks after the application.
Main outcome measure(s)

Safety and efficacy of protocol were evaluated at the sixth month postoperatively with tonal audiogram and visual analog scale, respectively.
Results

Mean average pure-tone hearing threshold at 0.5, 1, 2, 4, and 8 kHz was 49.6 and 51.0 dB before and after the application, respectively (P > .05).

Mean pretreatment and posttreatment visual analog scale scores of patients were 17.6 mm (10–30 mm) and 74.6 mm (41–100 mm), respectively (P < .01). Posttreatment VEMPs were absent in 17, deteriorated in 2, and not changed in 6 patients.

VEMP was a significant predictor of posttreatment visual analog scale score, whereas caloric test was not (P < .01). Conclusions

Low-dose, single-shot intratympanic gentamicin treatment proved to be effective and safe among intractable Ménière patients.

VEMPs obtained at posttreatment second week were significant predictors of patients posttreatment sixth-month dizziness status and vertigo control.

Corresponding Author Contact Information
Corresponding author. Ege Universitesi Hastanesi,
Kulak Burun Bogaz Bolumu, 35100,
Bornova, Izmir, Turkey.
Tel.: +902323902600; fax: +902323902670.

Fuente: American Journal of Otolaryngology
Volume 32, Issue 5, September-October 2011, Pages 412-416